2,2-difluoro-2-(3-fluorophenyl)acetic acid

2,2-difluoro-2-(3-fluorophenyl)acetic acid - Names and Identifiers

Name	2,2-difluoro-2-(3-fluorophenyl)acetic acid
Synonyms	2,2-difluoro-2-(3-fluorophenyl)acetic acid
CAS	1042623-00-6

2,2-difluoro-2-(3-fluorophenyl)acetic acid - Physico-chemical Properties

Molecular Formula	C8H5F3O2
Molar Mass	190.1193096
Storage Condition	2-8℃

2,2-difluoro-2-(3-fluorophenyl)acetic acid - Introduction

2,2-difluoro-2-(3-fluorophenyl)acetic acid is an organic compound. The following is an introduction to its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless crystalline solid
-Molecular formula: C8H5F3O2
-Molecular Weight: 194.12
-Melting point: 74-76 ° C
-Boiling point: 282-284 ° C
-Solubility: Slightly soluble in water, easily soluble in organic solvents such as ethanol and dimethylformamide

Use:
2,2-difluoro-2-(3-fluorophenyl)acetic acid is a multifunctional organic synthesis intermediate that can be used to synthesize drugs, pesticides and other organic compounds. It is used as a raw material for the synthesis of antiepileptic drugs in the pharmaceutical field, and can also be used to synthesize compounds with anti-breast and anti-renal cancer activities. In addition, it can also be used as a catalyst for other organic chemical reactions.

Method:
2,2-difluoro-2-(3-fluorophenyl)acetic acid can be obtained by the reaction of acetophenone and bromofluoroacetate. The specific preparation method is as follows:
1. First, acetophenone is added to anhydrous hydrofluoric acid for fluorination reaction to generate 2,2-difluoro -2-(3-fluorophenyl) ethanone.
2. Next, 2,2-difluoro-2-(3-fluorophenyl) ethanone is reacted with a base such as sodium hydroxide to give 2,2-difluoro-2-(3-fluorophenyl)acetic acid.

Safety Information:
Dust or vapor of 2,2-difluoro-2-(3-fluorophenyl)acetic acid may cause irritation to the eyes, skin, and respiratory tract. Wear appropriate protective equipment during handling to avoid direct contact. If contact occurs, immediately flush the affected area with water and seek medical help. When storing and using, please follow the safety procedures and keep it in a sealed container away from heat and fire sources.

Last Update：2024-04-09 21:01:54